Abstract
Background MiR-106b-25 cluster, hosted in intron 13 of MCM7, may play integral roles in diverse processes including immune response, tumorigenesis and progression. A single nucleotide polymorphism (SNP), rs999885, is located in the promoter region of MCM7. Our previous study showed that the A to G base change of rs999885 may provide an increased risk for HCC in HBV persistent carriers by altering the expression of the miR-106b-25 cluster. However, it is unknown whether rs999885 is associated with prognosis of intermediate or advanced HBV-related hepatocellular carcinoma (HCC) patients.MethodsThe SNP, rs999885, was genotyped by using the TaqMan allelic discrimination Assay in 414 intermediate or advanced HCC patients. Log-rank test and Cox proportional hazard models were used for survival analysis.ResultsThe variant genotypes of rs999885 were associated with a significantly decreased risk of death for intermediate or advanced HCC [additive model: adjusted hazard ratio (HR) = 0.76,95% confidence intervals (CI) = 0.59–0.97]. Further stepwise regression analysis suggested that rs999885 was an independently protective factor for the prognosis of HCC in the final model (additive model: adjusted HR = 0.72, 95% CI = 0.56–0.91, P = 0.007).ConclusionsThese findings indicate that the A to G base change of rs999885 may provide a protective effect on the prognosis of intermediate or advanced HCC in Chinese.
Highlights
Primary liver cancer is the sixth most common cancer worldwide
MiR-106b-25 cluster is located in intron 13 of MCM7 and our previous study [22] has showed that the A to G base change of rs999885 was associated with an increased risk of hepatocellular carcinoma (HCC) in HBV persistent carriers by altering the expression of the miR106b-25 cluster
In consideration of prognostic modeling in HCC patients has a high complexity and should consider several tightly related aspects, including tumor stage, degree of liver function impairment, patient’s general condition, and treatment efficacy, we use the Barcelona Clinic Liver Cancer (BCLC) Stage System to evaluate the prognosis of HCC in this study [25]
Summary
Primary liver cancer is the sixth most common cancer worldwide. Hepatocellular carcinoma (HCC), which represents the dominant histological type, accounts for 70–85% of primary malignancies in liver [1]. MiR-106b-25 cluster is located in intron 13 of MCM7 (minichromosome maintenance complex component 7) and our previous study [22] has showed that the A to G base change of rs999885 was associated with an increased risk of HCC in HBV persistent carriers by altering the expression of the miR106b-25 cluster. Our previous study showed that the A to G base change of rs999885 may provide an increased risk for HCC in HBV persistent carriers by altering the expression of the miR-106b-25 cluster It is unknown whether rs999885 is associated with prognosis of intermediate or advanced HBV-related hepatocellular carcinoma (HCC) patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
