Abstract
Marek’s disease (MD), caused by a herpes virus, is a very infectious, lymphoproliferative and chronic disease of poultry. Breeding for improved MD resistance poultry stock is possible since MD resistance has been associated with MHC haplotypes, QTL and candidate genes. However, integration of host genetics vis-à-vis other control strategies and the utilisation of genes or gene markers for MD in practical breeding programmes is still a challenge. The objective of the present study was to develop a basic genetic-epidemiological model for Marek’s disease infection in poultry, identify parameter spaces that describe the disease dynamics correctly and investigate the impacts of possible genetic and vaccination control strategies on overall disease dynamics.
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