Abstract
Adult zebrafish possess an elevated cardiac regenerative capacityas compared with adult mammals. In the past two decades, zebrafish have provided a key model system for studying the cellular and molecular mechanisms of innate heart regeneration. The ease of genetic manipulation in zebrafish has enabledthe establishment of a genetic ablation injury model in which over 60% of cardiomyocytes can be depleted, eliciting signs of heart failure. After this severe injury, adult zebrafish efficiently regenerate lost cardiomyocytes and reverse heart failure. In this chapter, we describe the methods for inducing genetic cardiomyocyteablation in adult zebrafish, assessing cardiomyocyte proliferation, and histologically analyzing regeneration after injury.
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