Abstract
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays a crucial role as a methyl-group donor in demethylation of homocysteine. The aim of this systematic review and meta-analysis was to study the relationship between MTHFR gene polymorphism and metabolic syndrome (MS). We used search engines and databases such as Science Direct, Google Scholar, Embase, Cochrane Library, and PubMed to identify eligible studies up to 2018. The articles were studied based on keywords including MTHFR, mutation, variant, and polymorphism in combination with MS. Data was analyzed using Comprehensive Meta-Analysis version 2.2.064 software. After extracting the data from seven articles, the total number of subjects was 1280 in the patient group and 1374 in the control group. The odds ratio was estimated to be 1.078 for the allele model of T vs. C (95% confidence interval [CI]: 1.626-0.715), 1.157 for the allele model of CC vs. CT (95% CI: 0.829-1.615), 1.020 for the allele model of CT + TT vs. CC (95% CI: 1.611-0.646) and 0.799 for the allele model of TT vs. CC + CT (95% CI: 1.185- 0.539). As well, the results showed no statistically significant correlation between polymorphism genotypes of the MTHFR gene and MS (P<0.05). In general, this study showed that the presence of C677T polymorphism in the MTHFR gene has no effect on the incidence of MS.
Highlights
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays an important role as a methyl-group donor in de- GMJMTHFR Polymorphism and Risk of Metabolic Syndrome zyme, resulting in the formation of a temperature-sensitive enzyme and reducing its activity [2]
This relationship can be partially justified in light of the correlation of C677T polymorphism with hypertension [11], diabetes mellitus (DM) [12, 13], and diabetic nephropathy [14]
There has been a significant relationship between MTHFR and metabolic syndrome (MS) in certain groups of people with type 2 DM [15] and schizophrenia [16], but these studies have very different results in relation between MTHFR and MS, and no comprehensive study has been done to summarize these outcomes in patients with MS
Summary
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that plays an important role as a methyl-group donor in de-. The aim of this systematic review and meta-analysis was to study the relationship between MTHFR gene polymorphism and MS. Selected articles for meta-analysis had the following features: evaluation of the relationship between MTHFR gene and MS, number of subjects in case and control groups, access to distribution of genotypes and alleles in case and control groups, considering 95% confidence interval (CI) to estimate odds ratio (OR), original research articles, randomized and controlled articles, and considering gene polymorphism as the main independent variable. A P-value of less than 0.05 was considered as a significance level
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
