Abstract
AimThe CC chemokine ligand 5 (CCL5), plays a key role in the inflammatory response by recruiting mononuclear cells during tuberculosis (TB) infection. Association studies of CCL5 -28 C>G (rs2280788) polymorphism and TB risk have shown inconsistent and contradictory results among different ethnic populations. The aim of this meta-analysis is to investigate the association between CCL5 -28 C>G polymorphism and TB susceptibility.MethodologyWe performed quantitative synthesis for published studies based upon association between CCL5 -28 C>G polymorphism and TB risk from PubMed (Medline), EMBASE web databases. The meta-analysis was performed and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all genetic models.ResultsA total of six studies including 1324 TB cases and 1407 controls were involved in this meta-analysis. Variant allele (G vs. C: p = 0.257; OR = 1.809, 95% CI = 0.649 to 5.043), heterozygous (CG vs. CC: p = 0.443; OR = 1.440, 95% CI = 0.567 to 3.658) and homozygous (GG vs. CC: p = 0.160; OR = 5.140, 95% CI = 0.524 to 50.404) carriers did not show increased risk compare with those individual with the CC genotype. Similarly, no associations were found in the dominant (GG+CG vs. CC: p = 0.295; OR = 1.802, 95% CI = 0.599 to 5.412) and recessive (GG vs. CC+CG: p = 0.188; OR = 3.533, 95% CI = 0.541 to 23.085) models.ConclusionsOverall findings of this meta-analysis suggest that genetic polymorphism -28 C>G in CCL5 is not associated with increased TB risk. However, future larger studies with group of populations will be needed to analyze the relationship between the CCL5 -28 C>G polymorphism and risk of TB.
Highlights
Tuberculosis (TB) is the most common chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), leading cause of death with an estimate of approximately 1.5 million deaths worldwide annually [1], represents a major public health problem on a global scale
Overall findings of this meta-analysis suggest that genetic polymorphism -28 C.G in CC chemokine ligand 5 (CCL5) is not associated with increased TB risk
Future larger studies with group of populations will be needed to analyze the relationship between the CCL5 -28 C.G polymorphism and risk of TB
Summary
Tuberculosis (TB) is the most common chronic infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), leading cause of death with an estimate of approximately 1.5 million deaths worldwide annually [1], represents a major public health problem on a global scale. One-third of the world’s population is thought to be affected with M. tuberculosis infection but only small fraction (5–15%) of population develops an active TB disease during their lifetime [2]. The occurrence of TB at different rates indicates that complex interaction of M. tuberculosis with environmental and host genetic differences may contribute to development of TB infection [3]. It is widely accepted that genetic variants, especially those belong to immune system confer strongly influence susceptibility to active TB at the individual level [3,4]. It is anticipated that the identification of host genetic factors for susceptibility to TB would greatly aid the global control and therapeutic strategies of this infectious disease
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