A genetic analysis identifies haplotype at adiponectin locus: Association with the metabolic health and obesity phenotypes.

Abstract

Obesity and metabolic syndrome frequently co-exist and define obese individuals into different obesity phenotypes, such as metabolically healthy obese (MHO), metabolically unhealthy obese (MUO) and metabolically unhealthy normal weight (MUNW). Growing evidence suggests that genetic predisposition and environmental factors can explain the heterogeneity among these phenotypes. We conducted a case-control study including 130 MHO, 251 MUNW, 208 MUO and 336 health controls by genotyping 2 SNPs (rs2241766, rs1501299) in ADIPOQ to investigate possible associations between SNPs in the ADIPOQ gene with susceptibility to three obese phenotypes respectively in Chinese Han population. Unconditional logistic regressions were used to detect the association between ADIPOQ SNPs and MHO/MUNW/MUO risks. Variant G allele of rs2241766 was associated with a reduced odds of MUO (additive model: Adjusted OR=0.55; 95% CI=0.40-0.75; P<0.001) and no evidence of any significant association between rs2241766 and MHO phenotype (additive model: Adjusted OR=0.84; 95% CI=0.61-1.16; P=0.306) or MUNW phenotype (additive model: Adjusted OR=0.95; 95% CI=0.73-1.24; P=0.720) was found. Minor allele T of rs1501299 were significantly associated with decreased risk of MHO (Adjusted OR=0.53; 95% CI=0.37-0.76; P<0.001) and MUNW (Adjusted OR=0.63; 95% CI=0.48-0.83; P=0.001) in additive genetic model after correction for multiple testing. The variant G allele of rs2241766 was negatively associated with risk of MUO and variant T allele of rs1501299 exhibited reduced odds for MHO and MUNW. Beyond that, future studies are warranted to validate and extend our findings.