Abstract
A short three-step synthesis of tetrasubstituted 3,3a,5,6-tetrahydro-2H-pyrazolo[3,4-d]thiazoles has been worked out. This relatively unknown heterobicyclic system is assembled from two carbonyl compounds, an amine, a hydrazine, and mercaptoacetic acid ester. These versatile starting materials allow the introduction of a broad range of alkyl, haloalkyl, cycloalkyl, aryl, and heteroaryl substituents into four different positions of the bicyclic scaffold. The efficiency of the synthesis route is proven by the fact, that two of the three steps are a multicomponent reaction or a cascade reaction, respectively, and that it can further be shortened to two consecutive one-pot processes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
