Abstract
We have established a new general synthesis for (±)-dibenzocyclooctadiene lignans, including (±)-schizandrin (la), (±)-gomisin A (1b), (±)-isoschizandrin (3a), and (±)-isogomisin A (3b), via the spiro-dienone ethers E- and T-11 as the key intermediates, prepared from the corresponding bisarylbutanol derivatives E- and T-10 by the oxidation with Weitz' aminium salt, tris(4-bromophenyl)aminium hexachloroantimonate (BAHA). These syntheses consist of 13 steps from the phenylpropanone 5
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