Abstract
A highly selective synthetic route of general utility was devised for the preparation of 2'-hydroxychalcones 4. The procedure involves the regiochemical controlled reaction between bromomagnesium salts of mono and dihydric phenols 1 and variously substituted cinnamaldehydes 2 in aprotic apolar media and in the presence of a suitable basic additive. Application of this procedure to some naturally occurring chalcones is reported. The crucial role of the additive is also emphasized.
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