A General Strategy for Synthesis of Heterocyclic Hemiketal‐Containing α,β‐Unsaturated Ketones from Ynediones

Abstract

AbstractA general strategy for synthesis of heterocyclic hemiketal‐containing α,β‐unsaturated ketones has been established. Using the environmentally sound and readily available reagents water and thiourea applied to ynediones, a series of sensitive hemiketals of 3(2 H)‐furanones and 3(2 H)‐thienones were constructed under mild conditions. Both of the reaction conditions are compatible with a diverse range of functional groups. Isotopic labeling, tautomerism, and GC‐MS tracking methods were used to reveal the mechanisms.