Abstract
A convenient general method of halogenations suitable for synthesis of α-halodifluoromethyl ketones is reported. Reaction of 2,2-difluoro-1-aryl-1-trimethylsiloxyethenes (difluoro silyl enol ethers) ( 2a–e) with halogens at low temperature (−30 to −78 °C) produced a high yield of α-halodifluoromethyl ketones ( 1a–j). This one-step simple method can be highly useful for synthesis of [ 18 F ]-labeled α-trifluoromethyl ketones.
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