Abstract
AbstractA new approach to asymmetric synthesis of γ‐aminophosphonic acids is described. It involves the diastereoselective addition of various carbon and phosphorus nucleophiles to enantiopure (+)‐(S)‐N‐[(3‐diethoxyphosphoryl)propylidene]‐p‐toluenesulfinamide and subsequent acid hydrolysis of the adducts formed. The utility of the method is illustrated by the synthesis of (+)‐(S)‐2‐ amino‐4‐phosphonobutanoic acid (AP4), and both enantiomerically enriched (–)‐(R)‐ and (+)‐(S)‐1‐amino‐propane‐1,3‐diphosphonic acid. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:594–598, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20710
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
