Abstract
The first general [18F]AIF automated radiolabelling procedure developed on the GE Tracerlab FX FN (Left) and Trasis AllInOne (Right) platforms.
Highlights
Positron emission tomography (PET) is an imaging modality used to diagnose and stage diseases by quantitatively monitoring the in vivo distribution of a positron emitting radionuclide bound by chelation or covalent bonding to a biological targeting molecule
Automated processes are typically required for the production of good manufacturing process (GMP) compliant fluorine-18 radiopharmaceuticals
Automation of radiopharmaceutical production is desirable to reduce the risk to patients by enabling batch reporting/record keeping, management control and standardisation of processes through the use of standard operating practices (SOPs)
Summary
Positron emission tomography (PET) is an imaging modality used to diagnose and stage diseases by quantitatively monitoring the in vivo distribution of a positron emitting radionuclide bound by chelation or covalent bonding to a biological targeting molecule. PET radioisotope due to a combination of its high positron emission (97%), low positron energy (β + max = MeV). Investigation into the direct radiolabelling of biomolecules with fluorine-18 yielded a one-step procedure comprising the chelation of the aluminium fluoride-18 complex ([18F]AlF) by a macrocyclic ligand (i.e. NOTA, NODA).[4,5,6,7]. The rapid [18F]AlF technique has generated significant interest owing to the combination of convenient metal based radiochemistry and the excellent decay characteristics of fluorine-
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