Abstract
Advanced neuroimaging has revealed that slowly expanding lesions with a paramagnetic iron rim are the most common lesion type in progressive multiple sclerosis (pMS) and correlate with disability. Iron accumulation in the activated microglia and macrophages at the edge of these lesions is governed by inflammatory pathways and may contribute to the pathogenesis of pMS. We investigated whether genetic variants in genes involved in iron metabolism may have an impact on pMS.
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