Abstract
6032 Background: Extracapsular spread and positive microscopic surgical margins are known high risk factors of recurrence in head and neck cancer patients. However, molecular biological markers to predict recurrence have not been identified. Here, we aimed to identify markers of recurrence using DNA microarray profiling in patients with squamous cell carcinoma of the tongue (TSCC). Methods: We conducted exploratory Affymetrix gene expression profiling using 26 primary tumor tissue samples from patients meeting the following criteria: 1) histologically confirmed TSCC, 2) surgical resection of the primary tumor and lymph node dissection, and 3) follow-up for longer than one year after surgery. Median age and pathological stage were 60 years (37-85) and pStageIII/IV = 8%/92% (pT: 2/3/4a = 3/1/22, pN: 0/1/2a/2b/2c = 5/5/0/8/8), respectively. The relationship between gene expression pattern and relapse-free survival (RFS) was examined. Predictive candidate genes were independently validated using published sur...
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