A gender-specific association of interleukin-1 receptor antogonist (IL1Ra) polymorphism with schizophrenia susceptibility

Abstract

Event Abstract Back to Event A gender-specific association of interleukin-1 receptor antogonist (IL1Ra) polymorphism with schizophrenia susceptibility Besma T. Bel Hadj Jrad1* and Mouna Ben Nejma1 1 higher institute of biotechnology, Tunisia Objective: Recent genetic studies have revealed that the IL1 gene complex is associated with schizophrenia in the Caucasian population; however, data from north-african population are underrepresented. In order to further assess the role of IL1Ra in schizophrenia, we examined a functional multiallelic polymorphism localized in the intron 2 of this receptor gene associated with altered level of IL1Ra. Methods: In the present case/controlled study, we have analyzed the (86pb)n polymorphism of the IL1-RN gene by PCR genotyping in 247 patients with schizophrenia and 150 healthy controls from the Tunisian population. Results: We showed that the frequencies of IL1RN*2/2 genotype and allele 2 were higher in the patient group vs. the control one, and the difference was statistically significant (13.8% vs. 3.3%, p=10-3, OR=5.8 and 35.2% vs. 20.3%, p=10-4, OR=2.1 respectively). When we have evaluated the association between this genetic polymorphism and the clinical variables of schizophrenia, we found that the frequency of the 2/2 genotype and the allele 2 were significantly higher in the male patients group (p=5.10-4 and p=10-4 respectively) compared to the male control group, indicating a substantially increased risk for sex-onset schizophrenia with inheritance of the IL1RN2 allele. Conclusion: the intron 2 polymorphism in IL1RN or a genetic polymorphism at proximity seems to be associated specifically with schizophrenia in the Tunisian male population. Acknowledgements We thank the staff of the department of Blood bank and Psychiatry of the CHU F. Bourguiba of Monastir for providing samples and clinical informations. Keywords: Single Nucleotide Polymorphisms (SNP), Interleukin1, Neuroinflammation, Schizophrenia, case-control study Conference: 4th Conference of the Mediterrarnean Neuroscience Society, Istanbul, Turkey, 30 Sep - 3 Oct, 2012. Presentation Type: Poster Presentation Topic: Abstracts Citation: Bel Hadj Jrad BT and Ben Nejma M (2013). A gender-specific association of interleukin-1 receptor antogonist (IL1Ra) polymorphism with schizophrenia susceptibility. Conference Abstract: 4th Conference of the Mediterrarnean Neuroscience Society. doi: 10.3389/conf.fnhum.2013.210.00007 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Mar 2013; Published Online: 11 Apr 2013. * Correspondence: Prof. Besma T Bel Hadj Jrad, higher institute of biotechnology, monastir, Tunisia, bbhj2002@yahoo.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Besma T Bel Hadj Jrad Mouna Ben Nejma Google Besma T Bel Hadj Jrad Mouna Ben Nejma Google Scholar Besma T Bel Hadj Jrad Mouna Ben Nejma PubMed Besma T Bel Hadj Jrad Mouna Ben Nejma Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.