Abstract
A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca2+ from nHA can form a [HO]Ca2+ [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.
Highlights
Bone repair is a dynamic process in which osteoprogenitor cells are recruited to the bone defect site by a combination of various cytokines and growth factors, which are guided to differentiate into osteoblasts [1,2]
Bone tissue engineering is proposed on this basis and is a new method to promote bone repair and regeneration [6]
Common bone tissue scaffold materials can be divided into artificial synthetic materials, natural derived materials, and composite scaffold materials
Summary
Bone repair is a dynamic process in which osteoprogenitor cells are recruited to the bone defect site by a combination of various cytokines and growth factors, which are guided to differentiate into osteoblasts [1,2]. For patients with severely injured bone defects, osteoporosis or congenital skeletal deformities, the process of bone self-healing is slow and limited [3,4]. Manual intervention is necessary to increase bone mass, such as bone transplantation, bone cement or medication. Bone tissue engineering is proposed on this basis and is a new method to promote bone repair and regeneration [6]. The scaffold material used provides structural support, promotes cell adhesion, proliferation, and creates favorable conditions for differentiation, thereby achieving bone mass increase and functional recovery at the bone defect site [7,8]. Common bone tissue scaffold materials can be divided into artificial synthetic materials, natural derived materials, and composite scaffold materials
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
