Abstract
A Gateway between Recent and Remote Memory
Highlights
Maintaining memories over time requires a highly dynamic process of brain activation based on time-dependent recruitment of subcortical and cortical regions (Frankland and Bontempi, 2005; Squire and Bayley, 2007)
Evidence has accumulated that long after a memory is formed, the HPC is disengaged in favor of medial prefrontal cortex regions including the anterior cingulate (Restivo et al, 2009), the infralimbic (Vetere et al, 2011b) and the orbitofrontal cortices (Lesburgueres et al, 2011)
In contrast with the intuitive idea that the neocortex might exclusively be dedicated to the storage of remote memory traces, it has been recently shown that lesions to lateral entorhinal cortex disrupt both recent and remote memory (Morrissey et al, 2012)
Summary
Maintaining memories over time requires a highly dynamic process of brain activation based on time-dependent recruitment of subcortical and cortical regions (Frankland and Bontempi, 2005; Squire and Bayley, 2007). Evidence has accumulated that long after a memory is formed, the HPC is disengaged in favor of medial prefrontal cortex (mPFC) regions including the anterior cingulate (Restivo et al, 2009), the infralimbic (Vetere et al, 2011b) and the orbitofrontal cortices (Lesburgueres et al, 2011). MPFC neurons are active during the recall of remote memories and their neuronal firing became selective for the association formed during the learning episode (Takehara-Nishiuchi and McNaughton, 2008).
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