Abstract
A gas chromatographic method has been developed which enables accurate and specific quantitative determinations in plasma and urine of the tricyclic antidepressant drug nortriptyline and some of its desmethylated or hydroxylated metabolites and their conjugates formed in vivo. The compounds are extracted as bases into hexane (the conjugated metabolites after hydrolysis) and, after a clean-up procedure, derivatized with heptafluorobutyric anhydride. The heptafluorobutyryl derivatives are separated on a gas chromatograph equipped with an electron capture detector. Accurate determination are possible in concentrations down to 10 ng/ml.
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