Abstract
A gas chromatographic method for the qualitative and quantitative determination of haloperidol in plasma at therapeutic levels has been developed. The procedure involves extraction of the drug from alkalinized plasma into n-heptane, successive concentration into aqueous and organic solvents, and separation on a gas-liquid chromatograph equipped with an electron capture detector. The method has been applied to plasma samples from patients receiving 9 to 15 mg of haloperidol pro die. Plasma levels encountered after oral doses of 3 to 5 mg varied from zero to 10 ng of haloperidol per ml of plasma.
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