Abstract
Introduction: Euphorbia tirucalli L. is a medicinal plant popularly distributed in Asian countries. In Vietnam, only one study on the polar extract the plant Euphorbia tirucalli growing in Binh Thuan province, Vietnam was reported, revealing several phenolic components. As of 2019, no chemical reports on the non-polar extract from the Vietnamese plant were found. This research described the isolation and elucidation of compounds isolated from the non-polar extract of E. tirucalli growing in Binh Thuan province.
 Method: The n-hexane extract of this plant was carried out by using normal phase silica gel column chromatography, thin-layer chromatography, and gel chromatography (Sephadex LH-20). Analysis of spectroscopic data and a comparison of the NMR data with that in the literature led to the structural elucidation of isolated compounds.
 Results: Three terpenoid compounds, euphol (1), lupenone (2), and vomifoliol (3), along with ergosterol peroxide (4), ferulic acid (5), and vanillic acid (6) were isolated and elucidated.
 Conclusions: Among them, compound 3 and 4 were reported in the first time from E. tirucalli.
Highlights
Euphorbia tirucalli L. is a medicinal plant popularly distributed in Asian countries
Euphorbia tirucalli L. is a shrub or small tree widely distributed in Africa, Asia, and Indochina and is a medicinal plant in various tropical countries 1
As a continuation of our research focused on the diversity of bioactive metabolites from Vietnamese medicinal plants 4,5, the phytochemical study was performed on the less polar extract of the title plant
Summary
Euphorbia tirucalli L. is a shrub or small tree widely distributed in Africa, Asia, and Indochina and is a medicinal plant in various tropical countries 1. Pharmacological properties of E. tirucalli indicated diverse bioactivities, comprising antioxidant and antimicrobial, antifungal, antiviral, anti-inflammatoryand cytotoxicity, as well as enzyme inhibitory activities. Chemical profile of this plant provided three common skeletons such as terpenoids, polyphenols, and tannins 1–3. As a continuation of our research focused on the diversity of bioactive metabolites from Vietnamese medicinal plants 4,5, the phytochemical study was performed on the less polar extract of the title plant. Their structures were elucidated from analysis of 1D and 2D NMR along with a comparison with literature reports. We report on the structure elucidation and isolation of six compounds
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