Abstract
A new fungal nonribosomal peptide-polyketide hybrid synthase, namely CogA, was discovered by genome mining from fungus Cordyceps gunnii. Its ability to synthesize 4-hydroxyl 2-pyrrolidinone alkaloid (1) via nonenzyme-catalyzed N-1-C-2 closure was confirmed by heterologous expression of it in Aspergillus nidulans. Further engineered biosynthesis of the fluoro-substituted 2-pyrrolidinone alkaloid analogues (4 and 5) has also been achieved in vivo.
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