Abstract
The sodium leak channel (NALCN) is a member of the 24-transmembrane domain (24-TM) cation channel superfamily that includes the voltage-gated sodium and calcium channels (NaVs and CaVs). As its name suggests, NALCN is responsible for a constitutive Na+ conductance that controls neuronal excitability underlying respiration, circadian rhythm and locomotion. Multiple lines of evidence now support that NALCN forms a channelosome with specialised auxiliary subunits, namely UNC79, UNC80 and FAM155A. Intrigued by the possibility that additional components may associate with this megadalton protein complex, we screened miscellaneous non-conducting auxiliary subunits of ion channels (NaVβ1-4, CaVβ1, γ2, α2δ1, etc.) to search for protein(s) that regulate NALCN function.
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