Abstract
A system using a liquid-core waveguide for the full scanning of capillary electrophoresis processes is presented. The system utilizes the liquid-core waveguide as an efficient window for the excitation of separated samples and the collection of light through total internal reflectance, with zeptomolar detection limits. Scanning the excitation laser along the length of the electrophoresis capillary excites individually separated analyte bands, while the fluorescence is collected end-on by an optical fiber coupled to a photomultiplier. A new procedure for denoising and deconvolution was applied to the experimental electropherograms, removing the noise and resolving the highly overlapped peaks observed in early stages of the separation.
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