A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

Eliana M Coccia,Giovanna Romeo,Ahuva Nissim,Giovanna Marziali,Roberto Albertini,Elisabetta Affabris,Angela Battistini,Gianna Fiorucci,Roberto Orsatti,Giovanni B Rossi,Judith Chebath

doi:10.1016/0042-6822(90)90292-y

A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication

Eliana M Coccia, Giovanna Romeo + Show 9 more

https://doi.org/10.1016/0042-6822(90)90292-y

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Journal: Virology	Publication Date: Nov 1, 1990
Citations: 108

Affiliation: Istituto Superiore di Sanità, Istituto per le Tecnologie Didattiche, Institute of Biomedical Technologies, University of Messina, University of Parma, Weizmann Institute of Science

#Encephalomyocarditis Virus #VSV Replication + Show 8 more

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Abstract

Treatment of cells with interferons (IFNs) induces resistance to virus infection. The 2′-5′oligo A (2-5A) synthetase/RNase L is one of the pathways leading to translation inhibition induced by IFN treatment. A murine cDNA encoding the 43-kDa 2-5A synthetase was cloned and sequenced. NIH-3T3 cell clones transfected with this cDNA expressed the enzymatic activity to various extents and exhibited resistance to encephalomyocarditis virus (EMCV) but not to vesicular stomatitis virus replication. The specific resistance to EMCV can be attributed to 2-5A synthetase.

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