Abstract
Hydrogen sulfide (H2S) is an endogenously produced gaseous signaling molecule with multiple biological functions. In order to detect the biological H2S, here a new FRET-based ratiomatric fluorescent probe was designed and synthesized for visualization of H2S in lysosomes. The probe displays good solubility, a marked yellow to blue emission color change in response of H2S and high H2S selectivity. Moreover, the probe could be used to detect of H2S in lysosomes with good biocompatibility.
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