Abstract
Isoniazid (INH)-induced hepatotoxicity remains a significant clinical problem, and the current mechanistic hypothesis is incomplete; it is simply referred to as metabolic idiosyncrasy,1 which is believed to involve cytotoxicity caused by bioactivation of acetylhydrazine,2 a metabolite of INH. However, this hypothesis is based on animal studies, involving characteristics that are very different from those that pertain to hepatotoxicity in humans, such as delayed onset. This issue therefore deserves a fresh look. Clinical Pharmacology & Therapeutics (2011) 89 6, 911–914. doi:10.1038/clpt.2010.355
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have