Abstract
BackgroundThe aim of this study was to develop a system of computerised analysis of digital images of posterior capsule opacification (PCO) that is evidence based, objective and freely available. The paper will present evidence for the reliability and validity of the developed system.MethodsThe system of PCO analysis was developed considering current published evidence on visual significance of PCO and additional investigative analysis of PCO images. Details of the image processing and analysis steps are discussed and a final system that measures an entropy score weighted toward proximity to central areas is described. In order to assess validity, the systems ability to measure PCO progression is assessed along with the visual significance of its final computerised scores. Reliability of the system is also assessed.ResultsThe final system runs successfully and is simple to use. Analyses of PCO by the system show an ability to detect early progression of PCO as well as detection of visually significant PCO. Images with no clinical PCO produce very low scores in the analysis. Reliability of the system of analysis is shown to be satisfactory.ConclusionThis paper presents a system of PCO analysis that is evidence based, objective and clinically useful. Substantial evidence is provided for its validity and reliability.
Highlights
The aim of this study was to develop a system of computerised analysis of digital images of posterior capsule opacification (PCO) that is evidence based and objective
The authors are currently working on a compiled version that would be usable without any other specialist software
A cross-hair appears on the image surface and the user clicks on the top left of the image's area of interest and on the bottom right, delineating the region that is to be measured
Summary
The aim of this study was to develop a system of computerised analysis of digital images of posterior capsule opacification (PCO) that is evidence based, objective and freely available. The main objective systems of analysis, POCO[2] and AQUA[3] systems are not freely available They do not incorporate whether PCO is peripheral or central into calculations and show limited evidence for validity. There is clearly a need for a universally acceptable measure of PCO [7] that would be objective enough for scientific analysis and yet not exclude the majority of researchers by its lack of free availability It should be based upon current evidence on the visual significance of PCO and be tested to (page number not for citation purposes)
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