A fractional order control model for Diabetes and COVID-19 co-dynamics with Mittag-Leffler function

Abstract

The aim of this paper is to present and analyze the fractional optimal control model for COVID-19 and diabetes co-dynamics, using the Atangana-Baleanu derivative. The positivity and boundedness of the solutions was shown by the method of Laplace transform. The existence and uniqueness of the solutions of the proposed model were established using Banach fixed point Theorem and Leray–Schauder alternative Theorem. The fractional model was also shown to be Hyers-Ulam stable. The model was fitted to the cumulative confirmed daily COVID-19 cases for Indonesia. The simulations of the total number of hospitalized individuals co-infected with COVID-19 and diabetes, at different face-mask compliance levels, when vaccination strategy is maintained reveals that the total number of hospitalized co-infection cases decreases with increase in face-mask compliance levels, while maintaining COVID-19 vaccination. The simulation results show that to curtail COVID-19 and diabetes co-infections, policies and measures to enforce mass COVID-19 vaccination and strict face-mask usage in the public must be put in place. To further cut down the spread of COVID-19 and diabetes co-infection, time dependent controls are added into the fractional model, and the obtained optimal control problem investigated via the Pontryagin’s Maximum Principle.