A four factor simplex optimization of a serially coupled open tublar columns gas chromatographic system

Abstract

AbstractOptimization of a gas chromatographic system with two capillary columns coupled in series in a single oven for the linear temperature programmed separation of a mixture of C1C10 hydrocarbons has been carried out using the simplex optimization method. The following four selectivity parameters were optimized: the initial temperature of the oven; the initial hold time; the temperature programmed rate; and the pressure at the mid‐point of the system. The optimization procedure was monitored by the Cp criterion.