A [formula omitted] conformation for inosine, the wobble nucleoside in some tRNA's

Abstract

The crystal structure of an orthorhombic form of inosine was determined from three-dimensional X-ray diffraction data. There are two crystallographically independent inosine molecules, both of which assume a syn conformation that is different from the conformations found in other crystalline forms of inosine. Apparently, inosine has considerable conformational freedom, a property that may be required at the “wobble” position of anticodon triplets.