Abstract

AbstractA formal synthesis of betamethasone from 5α‐pregnane‐3β,16β,20S‐triol is described. Key transformations are a bromination‐acetylation of triol, an SN2 reaction of the resulting C16α‐bromide with dimethylcopperlithium to get the required C16β‐methyl group, and a double hydroxylation to prepare the dihydroxyacetone side chain.

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