Abstract
4-Hydroxy-5-amino-6-phenyl-4-hexanolide has been synthesized under its cyclized form (lactone 5) from a very inexpensive chiral starting material, L-glutamic acid. The key steps were an original reduction of carbonyl of a ketone with n-Bu 3SnH in the presence of silica gel, followed by an SN 2 displacement of a mesylate group with sodium azide
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