Abstract
Recent studies have suggested that the echogenic sign in the area of the substantia nigra (SN) assessed by transcranial sonography (TCS) may be a useful diagnostic tool in parkinsonian disorders. 1 SN hyperechogenicity is defined as an enlargement of the echogenic area and is present in at least 82% of Parkinson’s disease (PD) cases compared with approximately 10% of healthy controls (HCs). 1 Previous studies have demonstrated that the prevalence of SN hyperechogenicity is stable in different age categories of HCs, 2,3
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