Abstract
Given the current global climate and health challenges, sustainability and cost-effectiveness are becoming unavoidable factors that must be considered in the development of new synthetic methodologies. In a recent publication, Kavthe et al. (R. D. Kavthe, K. S. Iyer, J. C. Caravez and B. H. Lipshutz, Chem. Sci., 2023, 14, 6399, https://doi.org/10.1039/D3SC01699D) have succinctly demonstrated how employing more sustainable methodology can vastly reduce the environmental impact associated with the synthesis of the antimalarial drug candidate MMV688533. The most notable feature of this newly reported synthetic route is the application of aqueous micellar conditions to two Sonogashira coupling reactions that simultaneously improve the yield, catalyst loading and sustainability of these key steps.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
