Abstract
AbstractA novel non‐fluorophoric chemodosimeter, 2‐[4‐Diethylamino‐2‐(4‐nitro‐benzyloxy)‐benzylidene]‐malonic acid diethyl ester (1) was developed for the estimation of hydrogen sulphide by exploitation of the ubiquitous reduction of nitro functionality to amino under mild conditions which culminated in the generation of the popular fluorescent moiety, coumarin via tandem nucleophilic addition‐elimination reaction made facile by the structure of the probe molecule. The coumarin moiety produced a brilliant blue fluorescence turn‐on response. Apart from its sensitivity, selectivity and successful application in cellular imaging, a remarkable feature of 1 is its capacity to detect H2S in garlic extract both in presence as well as absence of glutathione which is a crucial player in the pathway for the production of H2S from garlic extract.
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