Abstract
AbstractGlutathione (GSH), an oxidative stress biomarker plays a major role in different pathological processes and lead to a vast number of diseases including cancer. Biologically, cystine uptake is a fundamental factor in maintaining GSH levels in cells; however, the interaction between cystine and GSH in biological systems is least explored in developing sensors for GSH. In the present work, we have explored this interaction as the fundamental factor in “turn‐on” sensing of GSH from body fluids using a fluorescent gold nanocluster platform. The experimental results revealed that the probe displayed appreciable performance for GSH over a linear range from 0.2 mM to 1.3 mM with a limit of detection (LoD) of 0.43 μM. The probe also revealed sensitive as well as selective response towards GSH even in the presence of possible co‐existing interferants and provided satisfactory recovery percentage of 94.17 % to 108.12 % from real serum samples. These findings of the present study can be extended in future applications of sensing GSH from clinical samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
