Abstract
A new fluorescent probe NADH, namely N'1,N'3-bis((E)-(2-hydroxy- naphthalen-1-yl)methylene)isophthalohydrazide, derived from isophthalic dihydrazide and naphthaldehyde was synthesized and characterized. NADH displayed an excellent selectivity towards Al3+ over other cations with dual channel emissions (460 nm & 486 nm) in DMSO-Tris (v/v, 8:2) buffer solution. Job‘s plot analysis confirmed a 1:1 binding ratio between NADH and Al3+. NADH had a good anti-interference ability from most coexisted species according to competition study. The detection limit was estimated to be 0.219 μM by 3σ method, which was far below the acceptable limit in drinking water of WHO. A rational binding mode was proposed by means of Job’s plot and 1H NMR titration experiment. Furthermore, NADH was found to be biocompatible and it was applied to image intracellular Al3+ in living cells successfully.
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