Abstract
The pattern of distribution of chromocentres and nucleoli in interphase nuclei of fibroblast cells of laboratory mouse ( Mus musculus, 2 n = 40), tobacco mouse ( M. poschiavinus, 2 n = 2 6, with 7 pairs of metacentrics) and their F 1 hybrids has been studied using the fluorochromes quinacrine mustard (QM) and acridine orange (AO). The laboratory mouse had many more nucleoli and chromocentres cell than the tobacco mouse. The pattern of F 1 was very similar to that of the tobacco mouse, which may indicate a homologous association of the heterochromatin to form chromocentres. The interesting phenomenon of the ability of the mouse centromeric heterochromatin to bind QM in interphase though not in metaphase is reported.
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