Abstract
Salbutamol is a bronchodilator whose use is restricted due to its anabolic effects. A flow-based procedure for salbutamol determination based on the inhibition of chemiluminescence of the luminol/hypochlorite system was developed. A flow cell constructed with a liquid-core waveguide was employed to constrain the emitted radiation, minimizing losses during transport to detector. Linear response was observed within 2.5 × 10−6 and 1.0 × 10−5 mol L−1 with a detection limit estimated as 1 × 10−7 mol L−1 at the 99.7% confidence level. The coefficient of variation (n = 20), sampling rate, and luminol consumption per determination were estimated as 2.8%, 164 determinations h−1, and 50 µg, respectively. Results for pharmaceutical samples were in agreement with those obtained by reference procedures at the 95% confidence level.
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