Abstract
A flow-injection method is proposed for determining antiviral guanine derivatives, acyclovir, valacyclovir, ganciclovir, and famciclovir, based on their amperometric detection on a carbositall electrode with a preactivated surface. The method is characterized by a wide analytical range, relatively low detection limits (0.6–1.2 μg/mL), and high performance (75 h–1). The results of examination of the accuracy and reproducibility of the analysis of solutions of different pharmaceutical forms containing the test substances are presented. The potentials of the developed flow-injection method in the implementation of the “Dissolution” test in an automated mode are demonstrated.
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