Abstract
We report a 5‐step sequence for the synthesis of phosphatidylglycerols (PG) bearing different or identical chains at positions sn‐1 and sn‐2 starting from phenyl dichlorophosphate and using (S)‐glycidol as the chiral source. Overall, this new approach is more convergent that the previously reported syntheses as the PG derivatives are constructed around the phosphorus center. Hence, this method is more convenient for the incorporation of expensive or complex acyl chains at the sn‐2 position.
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