Abstract
Effects of Rosiglitazone and Acarbose (with and without Cornstarch Diet) on Serum Electrolytes in Diabetic RatsHumera Khatoonand Rahila Najam
Highlights
Hydrophilic matrices are a principal technology used for extended release (ER) oral dosage forms and their development is currently one of the most important challenges in pharmaceutical research (Shojaee et al, 2013)
Estimation of diltiazem hydrochloride (DTZ) content The HPLC method (El-Ashmawy, 2009) adopted to estimate DTZ content in fresh and five-year stored poly(ethylene oxide) (PEO) matrix tablets was found to be linear in the concentration range of 0.3–3.0 μg/ml
The DTZ content in different tablets was not less than 87.89 % (F1) and did not exceed 105.12 % (F3) of the labeled claim. This result indicated that all the prepared tablets were found to be within the accepted drug content limits of US-Pharmacopoeia, i.e., the average percentage of drug content of all formulae was found to be within the range of 85% and 115% of the label claim (Convention, 2007)
Summary
Hydrophilic matrices are a principal technology used for extended release (ER) oral dosage forms and their development is currently one of the most important challenges in pharmaceutical research (Shojaee et al, 2013). Polyethylene oxide (PEO) is among various hydrophilic polymers that, in the presence of water, form a hydrogel that could control the release of the active moiety either by swelling or by swelling/erosion. PEOs have been proposed as alternatives to cellulose or other ethylene glycol derivatives in the production of controlled release drug delivery systems (Emara et al, 2012; Jeong et al, 2002). There is limited and sometimes potentially conflicting data available in the literature regarding the stability of these polymer systems (Shojaee et al, 2013)
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