Abstract
BackgroundOsteosarcoma is a highly malignant and common bone tumour with an aggressive disease course and a poor prognosis. Previous studies have demonstrated the relationship between long noncoding RNAs (lncRNAs) and tumorigenesis, metastasis, and progression.MethodsWe utilized a large cohort from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database osteosarcoma project to identify potential lncRNAs related to the overall survival of patients with osteosarcoma by using univariate and multivariate Cox proportional hazards regression analyses. Kaplan–Meier curves were generated to evaluate the overall survival difference between patients in the high-risk group and the low-risk group. A time-dependent receiver operating characteristic curve (ROC) was employed, and the area under the curve (AUC) of ROC was measured to assess the sensitivity and specificity of the multi-lncRNA signature.ResultsFive lncRNAs (RP11-128N14.5, RP11-231|13.2, RP5-894D12.4, LAMA5-AS1, RP11-346L1.2) were identified, and a five-lncRNA signature was constructed. The AUC for predicting 5-year survival was 0.745, which suggested good performance of the five-lncRNA signature. In addition, functional enrichment analysis of the five-lncRNA-correlated protein-coding genes (PCGs) was performed to show the biological function of the five lncRNAs. Additionally, PPI network suggested RTP1 is a potential biomarker that regulates the prognosis of osteosarcoma.ConclusionsWe developed a five-lncRNA signature as a potential prognostic indicator for osteosarcoma.
Highlights
Osteosarcoma is a highly malignant and common bone tumour with an aggressive disease course and a poor prognosis
Our study suggests the potential functions of long noncoding RNAs (lncRNAs) in osteosarcoma
Results of the multivariate Cox proportional hazards model The multivariate Cox proportional hazards model was established with 5 lncRNAs (RP11-128N14.5, RP11231|13.2, RP5-894D12.4, LAMA5-AS1, RP11-346L1.2)
Summary
Osteosarcoma is a highly malignant and common bone tumour with an aggressive disease course and a poor prognosis. Osteosarcoma is a highly malignant and common bone tumour with an aggressive and poor prognosis and is prevalent in adolescents and young adults [1, 2]. 80% of osteosarcomas occur in the extremities, most commonly in the metaphysis of the long bone around the knee joint, and the other 20% occur in the axial bone and pelvis [3]. Metastasis, especially lung metastasis, is an important factor in determining the prognosis and survival of osteosarcoma. It has been reported that high-dose methotrexate, vincristine, and folinic acid could improve the survival rate of patients. The survival rate of patients with metastatic osteosarcoma remains unchanged [4]. We aimed to search for prognostic targets of osteosarcoma
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