Abstract
The monolayer-forming properties of milk and egg phospholipids and a synthetic model of human gastric mucosal phospholipids were studied by using a Langmuir film balance. Compression isotherms were constructed at pH 5.6 — the pH of unbuffered water — and at room temperature. Furthermore the pH was reduced to 2 and the temperature raised to 37°C in order to mimic the normal stomach environment. Milk egg and synthetic human gastric phospholipids formed liquid-expanded monolayers at the air-water interface. The increase in temperature to 37°C and the reduction of the pH to 2 caused only minor changes in monolaycr formation. In addition we investigated the interaction between a number of anti-inflammatory drugs (NSAIDs) and a monolayer at the air/water interface. Milk phospholipids were chosen as a representative example of monolayer-forming phospholipids. NSAIDs adsorbed from the subphase to the monolayer of milk phospholipids and increased the surface area of the monolaycr.
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