Abstract
There is a need for faster and more precise biosensors to identify a disease in medical diagnostics. Bond-rupture scanning is a new sensor technique by inducing antibody–antigen bonds to rupture from a transducer surface. A quartz crystal microbalance (QCM) oscillates horizontally, and can be used as a platform to measure the mass change on its surface. A high speed digital electronics system was demonstrated for the purposes of inducing and detecting bond rupture. A field-programmable-gate-array-based high speed transceiver board is controlled by a digital signal processor, as well as various graphical user interfaces for the end user interaction. Bond-rupture detection was carried out by rupturing modified beads as a biological element shaking off from the surface of a QCM. It took as little as 20 s in a scanning experiment. The advantages of the proof-of-concept QCM and bond-rupture detection are that it is quick, simple and capable of discriminating between specific and non-specific interactions.
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