Abstract
While routine semen analysis has been the cornerstone of the male fertility evaluation, we know that it is far from a perfect predictor of fertility, and there will be some couples who struggle to obtain a live birth despite the male having a normal semen analysis. Indeed, the World Health Organization semen analysis normal reference ranges were based on samples from fertile men (1). The LIFE study, a prospective observational cohort study of 501 couples, which looked at the relationship between routine semen parameters and time to pregnancy, found that on multivariate analysis, none of the routine semen parameters (volume, concentration, motility or morphology) were associated with time to pregnancy. Only male age and female body mass index (BMI) were associated with the time to pregnancy (2). From both this data and others, we know that the standard semen analysis is not a perfect predictor for male infertility (3). These limitations have led to the investigation of sperm DNA fragmentation as an adjunctive test to guide the management of the sub-fertile couple.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
