Abstract
An exhaustive characterization of the physicochemical properties of gum arabic (GA)-coated Fe3O4 magnetic nanoparticles was conducted in this work. These nanoparticles were obtained via the in-situ coprecipitation method (a fast single-step method) in two GA:Fe ratios, 10:1 and 20:1, respectively. Several experimental techniques were applied in the characterization process, all of them described below. Using Transmission Electron Microcopy images, they were shown to have spherical-like morphology with 11 nm diameter. The Fourier Transform Infrared spectra confirmed the attachment of the GA on the surface of the magnetic nanoparticles (MNPs), providing good colloidal stability from pH 7 to 8. The thickness of the coatings (1.7 nm and 1.1 nm) was determined using thermogravimetric measurements. A high specific absorption rate and superparamagnetic properties were determined using alternant and static magnetic fields, respectively. The GA-coated MNPs were non-cytotoxic, according to tests on HT-29 human intestine cells. Additionally, HT-29 cells were exposed to magnetic fluid hyperthermia at 530 kHz, and the induction of cell death by the magnetic field, due to the heating of GA-coated MNP, was observed.
Highlights
Published: 20 January 2022The use of nanostructured materials, such as nanoparticles (NPs), offers many interesting physical properties, which contrast with the observations of bulky materials [1]
All these properties are fundamental to carrying out trials of magnetic fluid hyperthermia (MFH), where the implantation of localized iron oxide magnetic nanoparticles (MNPs) helps to concentrate the energy in a chosen biologic tissue [6], where the temperature can be increased above
Some necrotic cells with disrupted membranes and irregular shapes were observed at 44 and 47 ◦ C (Figure 9c), reaching confluence values between 5–10%. These findings indicate that MFH treatment promotes the death of cells due to the heating of the MNP-GA2
Summary
Published: 20 January 2022The use of nanostructured materials, such as nanoparticles (NPs), offers many interesting physical properties, which contrast with the observations of bulky materials [1]. MNPs can be manipulated by high gradients of magnetic fields [1]. In the scope of the physicochemical area, the biocompatibility of MNPs is directly related to particle size, shape, hydrophilic nature, coating, and surface charge [4,5]. All these properties are fundamental to carrying out trials of magnetic fluid hyperthermia (MFH), where the implantation of localized iron oxide MNPs helps to concentrate the energy in a chosen biologic tissue [6], where the temperature can be increased above
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