Abstract
THE work of Till and McCulloch et al.1,2 has established the existence in mouse bone marrow of a cell-type capable of proliferating in the spleens of lethally irradiated isogenic mice, and of forming visible colonies, or nodules, which contain both differentiated haemopoietic cells and more ‘colony-forming units’. During an investigation in this laboratory, of the ability of cells taken from such colonies to protect other lethally irradiated recipients, it was noticed that prior splenectomy of the recipients markedly reduced survival. In contrast, we have found that when normal bone marrow cells are used, prior splenectomy generally improves survival. The following experiment was therefore carried out:
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