Abstract
Plasmodium vivax is the most common malaria-causing parasite in Asia and South America. It preferentially infects an immature red blood cell that accounts for only 1–2% of circulating blood. The limited supply of these cells, called reticulocytes, has made it difficult to study P. vivax in the lab. Now, researchers at the Singapore-MIT Alliance for Research and Technology report two microfluidic methods for purifying lab-grown reticulocytes, one of which calls to mind the game Plinko from the game show The Price Is Right ( Lab Chip 2020, DOI: 10.1039/c9lc01128e ). The team demonstrates that the cheap, microfluidic chip-based methods offer comparable purity and faster processing times than standard sorting methods. These purification methods could also help advance the field’s long-standing goal of manufacturing red blood cells for transfusions. Learn more at cenm.ag/cellsorter .
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